Dynamic Energy Budget theory for metabolic organisation
By S.A.L.M. Kooijman, 2010
Cambridge University Press, Great Britain
ISBN 9780521131919.
Order the book at Cambridge University Press. Costs about 40 euro
(paperback).
Errata,
Comments,
Summary of concepts,
First edition appeared in 1993
Second edition appeared in 2000
Dynamic Energy Budget (DEB) theory is a formal theory for the uptake
and use of substrates (food, nutrients, light) by organisms and their
use for maintenance, growth, maturation and propagation; it applies to
all organisms (microorganisms, animals, plants). The primary focus is
at individual level, from a life cycle perspective, with many
implications for sub- and supra-individual levels. The theory is
based on sound chemical and physical principles, and axiomatic in
setup to facilitate testing against data. It includes effects of
temperature and chemical compounds; aging is discussed as an effect of
reactive oxygen species, with tight links to energetics. The theory
also includes rules for the co-variation of parameter values, better
known as body size scaling and quantitative structure activity
relationships. Many well-known empirical models turn out to be
special cases of DEB theory and provide empirical support. Many
additional applications are illustrated using a wide variety of data
and species.
After 30 years of research on DEB theory, this third edition presents
a fresh update; since the second edition in 2000 some 140 papers
appeared in journals with a strong focus on DEB theory. The biannual
DEB tele-courses provided input to improve the presentation.
A lot of supporting material for this book is meanwhile developed and
freely available, such as software package DEBtool; one of its
toolboxes contains code that generates the figures of this book:
setting of data, model specification, parameter estimation, plotting.
By replacing data by that of your own, you have a convenient tool to
apply the theory.
This edition includes a new chapter on evolutionary aspects, discusses
methods to quantfy entropy for living individuals, isotope dynamics, a
mechanism behind reserve dynamics, toxicity of complex mixtures of
compounds, an updated aging module now also applies to demand systems,
new methods for parameter estimation, adaptation of substrate uptake,
the use of otoliths for reconstruction of food level trajectories, the
differentiated growth of body parts (such as tumours and organs)
linked to their function, and many more topics are new to this
edition.
Summary of Contents
- 1) Basic concepts
- Individuals as dynamic systems;
homeostasis is key to life;
effects of temperature on rates.
- 2) Standard DEB model in time, length & energy
- Assimilation;
reserve dynamics follows from homeostasis;
the kappa-rule for allocation to soma;
dissipation excludes overheads of assimilation and growth;
growth of structure;
reproduction exports reserve;
parameter estimation I.
- 3) Energy, compounds and metabolism
- Body size and composition;
classes of compounds in organisms;
macrochemical reaction equations;
isotope kinetics;
enzyme kinetics revisited;
classification of types of processing and of compounds;
number of SUs affects transformation rates;
inhibition and co-metabolism;
supply versus demand kinetics;
metabolic modes.
- 4) Univariate DEB models
- Changing feeding conditions;
changing shapes;
conservation of elements;
carbon, water, dioxygen and nitrogen balance;
conservation of energy;
thermodynamic aspects;
micro-chemical reaction equations;
isotope dynamics;
product formation;
parameter estimation II;
trajectory reconstruction.
- 5) Multivariate DEB models
- Extensions to more than one substrate, reserve and structural mass;
photosynthesis and plant development;
simultaneous nutrient limitation;
calcification.
- 6) Effects of compounds on budgets
- Ageing;
uptake kinetics;
energetics affects kinetics;
toxicants affect energetics.
- 7) Extensions of DEB models
- Details of specific processes, such as
networking via handshaking of SUs;
feeding;
digestion;
cell wall synthesis;
organelle-cytosol interactions;
pupae;
changing parameter values;
adaptation;
mother-foetus interactions.
- 8) Co-variation of DEB parameter values
- Intra- and inter-specific parameter variations;
QSARs;
interactions between QSARs and body size scaling relationships.
- 9) Living together
- Trophic interactions between organisms;
population dynamics;
food chains and webs;
canonical communities.
- 10) Evolution
- Before the first cells;
early substrates and taxa;
evolution of individuals as dynamic systems;
merging of individuals in steps;
multicellularity and body size;
from supply to demand systems;
life builds on life.
- 11) Evaluation
- Methodological aspects of energetics;
a weird world at small scale;
DEB models have many empirical models as special cases;
comparison with other approaches.
Available support for this book: